Immunity
Toothpaste

4.9

Toothpaste tablets featuring your daily dose of vitamins D3 + B12 
for better oral and systemic health.

Absorbed as you brush. No need to swallow.

Learn more

Immunity
Toothpaste

Toothpaste tablets featuring your daily dose of
vitamins D3 + B12 
for better oral and systemic health.

Absorbed as you brush. No need to swallow.

Learn more

4.9

245 Reviews

VEGAN

NON-TOXIC

SLS-FREE

DENTIST-CREATED

CRUELTY-FREE

FLUORIDE-FREE

PLASTIC-FREE

MADE IN U.S.

Five Reasons to Switch to Duo

Co-founded by Dentists

Smiling person in a white blazer standing by a floral arrangement.

Stevie A. Roberts,

DMD

Founder of the dental practice Dentiste Kirkland in Seattle, WA, Dr. Roberts co-founded Duo toothpaste to bring better, science-backed ingredients to toothpaste tablets that work.

Smiling man wearing a white coat and tie with a gray background.

Robert E. Johnson,

DMD, MD

A graduate of the Department of Oral and Maxillofacial Surgery at the University of Washington. Dr. Johnson co-founded Duo with a commitment to oral and whole-body health.

Trusted by the industry

Two hands forming a heart shape against a colorful sunset background.'Logo with the letters RDH in black font.'Two hands forming a heart shape against a colorful sunset background.'Dental Economics magazine cover featuring industry-related content.''MyDental Advocate logo with a tooth graphic.'
'Black logo of the word 'duo' in lowercase letters.'

Standard
Toothpaste

Plastic-Free + Compostable Refills

Nano-Hydroxyapatite (Fluoride-Free) 

Vitamins & Supplements

SLS-Free & NO Harsh Chemicals

Hydrating Foam + Natural Flavors 

Reduces Sensitivity Without Numbing Agents

How to Brush with Duo

Man holding a toothbrush and a small bottle, wearing a blue shirt.

1

Grab a Duo tablet

Man holds toothbrush and bottle, smiling with tablet in mouth.

2

Crush a tablet between your teeth

Man in blue holding a duo flossing product, smiling and demonstrating use.

3

Brush to activate foam

Smiling person in a blue shirt pointing towards the camera.

4

Spit and smile

Subscribe or Purchase One-Time

whitens naturally 

without bleaching

nano-hydroxyapatite

for remineralizing teeth

antioxidants

for gum health

vitamin D3 (30mcg)

to bolster defenses

vitamin B12 (6mcg)

for mood support

vitamins absorbed

directly while brushing

Brown bottle of Duo Whitening Toothpaste tablets with immunity support, containing vitamin D and B12.Duo Whitening Toothpaste pack and bottle for immunity with vitamins D and B12, 62 tablets.

vitamin D3 + vitamin B12

Sleep Whitening

Toothpaste Tablets

4.9

167 Reviews

Prepare for a great night’s sleep with Duo tablets for relaxation and rest. We topped off our signature oral microbiome-balancing tablets with a perfectly portioned dose of melatonin (1.5mg), L-theanine (2.5mg), and lavender to regulate circadian rhythms, ease stress, and ready your system for nourishing rest.

1 Bottle (62 tablets) 

1 Bottle (62 tablets) 

1 Bottle (62 tablets) 

Every 2 Months

***

Subscribe to

save up to 33%

$18.00

$12.00/month

Save 33%

$18.00

$12.00/month

Save 33%

$18.00

$12.00/month

Save 33%

*** Subscriptions include glass printed bottles of Sleep and Original (1 of each) that hold 62 tablets each along with refills that come in compostable pouches. 

+ 100% Guaranteed - return for full refund if not satisfied
+ Free shipping on all orders over $20

VEGAN

NON-TOXIC

SLS-FREE

DENTIST-CREATED

CRUELTY-FREE

FLUORIDE-FREE

PLASTIC-FREE

MADE IN U.S.

VEGAN

NON-TOXIC

SLS-FREE

DENTIST-CREATED

CRUELTY-FREE

FLUORIDE-FREE

PLASTIC-FREE

MADE IN U.S.

Plastic free
for the planet

Duo is delivered in apothecary-grade, recyclable glass bottles. Subscription refills come in compostable pouches. It’s the future of toothpaste and better for all of us.

500
years

to break down a
single plastic
toothpaste tube

1.5

billion

plastic tubes
end up as trash
each year

Bottle labeled 'Duo Whitening Toothpaste' with tablets being poured from a packet.

Plastic free
for the planet

Duo is delivered in apothecary- grade, recyclable glass bottles. It’s the future of toothpaste and better for all of us.

500
years

to break down a
single plastic
toothpaste tube

1.5

billion

plastic tubes end up as trash each year

Reviews

4.8
Rated 4.8 out of 5 stars
Based on 277 reviews
277 reviews
  • CC
    Carole C.
    Verified Buyer
    Immunity
    Reviewing
    Immunity
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    A new way to clean your teeth

    I just started using Duo. It leaves your mouth fresh, and your teeth super clean. It feels as good as a dentist's

    cleaning. I have trouble using regular adult tooth paste(it burns in my mouth) Duo does not.

  • ME
    Mandie E.
    Verified Buyer
    Day/Night Bundle
    Reviewing
    Day/Night Bundle
    I recommend this product
    Rated 5 out of 5 stars
    Yesterday
    Love them both!

    I gave these a try looking for a good, clean toothpaste as several that I have tried have left my teeth looking more stained and feeling more sensitive. I have been using the Day/Night bundle now for a couple of weeks and love it! I do not have any tooth sensitivity now and I feel like my teeth are getting whiter! Will definitely be reording.

  • LS
    Laura S.
    Verified Buyer
    Immunity
    Reviewing
    Immunity
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago
    Cleans Really Well

    Love the way my teeth feel after brushing smooth and very CLEAN, I think it actually leaves a coating on your teeth that prevents some foods from sticking. I've used the tablets for just 2 weeks so far. There does seem to be a reduced sensitivity to hot & cold, but as far as building back enamel on the teeth. Not sure yet, maybe I will know after a future dentist visit?

  • CB
    Cheryl B.
    Verified Buyer
    Immunity
    Reviewing
    Immunity
    I recommend this product
    Rated 5 out of 5 stars
    3 days ago
    Great toothpaste

    Love this toothpaste. Mouth feels fresh and teeth feel super clean like after visiting the dentist!

Reviews LoadedReviews Added